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2018 08 25 Single-cell functional genomics



Single-cell functional genomics

1 Gene expression distribution deconvolution in single-cell RNA sequencing. Wang J, Huang M, Torre E, Dueck H, Shaffer S, Murray J, Raj A, Li M, Zhang NR. Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):E6437-E6446. doi: 10.1073/pnas.1721085115. Epub 2018 Jun 26.

2 CellAtlasSearch: a scalable search engine for single cells. Srivastava D, Iyer A, Kumar V, Sengupta D. Nucleic Acids Res. 2018 Jul 2;46(W1):W141-W147. doi: 10.1093/nar/gky421.

3 A Single-Cell Transcriptomic Atlas of Thymus Organogenesis Resolves Cell Types and Developmental Maturation. Kernfeld EM, Genga RMJ, Neherin K, Magaletta ME, Xu P, Maehr R. Immunity. 2018 Jun 19;48(6):1258-1270.e6. doi: 10.1016/j.immuni.2018.04.015. Epub 2018 Jun 5.

4 Single-cell transcriptomics to explore the immune system in health and disease. Stubbington MJT, Rozenblatt-Rosen O, Regev A, Teichmann SA. Science. 2017 Oct 6;358(6359):58-63. doi: 10.1126/science.aan6828. Review.

5 Single Cell Multi-Omics Technology: Methodology and Application. Hu Y, An Q, Sheu K, Trejo B, Fan S, Guo Y. Front Cell Dev Biol. 2018 Apr 20;6:28. doi: 10.3389/fcell.2018.00028. eCollection 2018. Review

6 Defining Cell Identity with Single-Cell Omics. Mincarelli L, Lister A, Lipscombe J, Macaulay IC. Proteomics. 2018 Apr 12:e1700312. doi: 10.1002/pmic.201700312. [Epub ahead of print] Review.

7 Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR. Zemmour D, Zilionis R, Kiner E, Klein AM, Mathis D, Benoist C. Nat Immunol. 2018 Mar;19(3):291-301. doi: 10.1038/s41590-018-0051-0. Epub 2018 Feb 12. Erratum in: Nat Immunol. 2018 May 3;:.

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Introduction

Gene network

"Human beings are ultimately nothing but carriers-passageways- for genes. They ride us into the ground like racehorses from generation to generation. Genes don't think about what constitutes good or evil. They don't care whether we are happy or unhappy. We're just means to an end for them. The only thing they think about is what is most efficient for them." Murakami Haruki, 1Q84

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